Salivary DNA Loads for Human Herpesviruses 6 and 7 Are Correlated With Disease Phenotype in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Front Med (Lausanne) · 2021 · PMC8378328 · PMID 34422848

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

borderline significanceP = 0.073so close (0.05 < p ≤ 0.1)

There was a trend toward higher HHV-6B DNA concentration in ME/CFS-MM participants than HC, with borderline significance at months 3 ( P = 0.073) and 5 ( P = 0.080).

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highly significantno p-value reported

In the pattern 1 ME/CFS_SA group (fluctuating levels of HHV DNA in saliva) there were strong and highly significant associations between HHV-6B DNA concentration and six symptom domain scores (sleep dysfunction, pain, neurocognition, autonomic, neuroendocrine and immune, r = 0.47, 0.52, 0.65, 0.50, 0.46, and 0.41, respectively, all P ≤ 0.01).

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