Indeed, we observed a trend towards significance in inflation of the GWAS association signal for variants that are cis -eQTLs for the top-ranked genes from the CRISPR screen in the SARS-CoV-2 reported infection GWAS, compared to all lung cis -eQTLs ( λ 0.1 = 1.78, permutation P value = 0.070, Fig. 1a ).
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Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.
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