Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.

A large meta-analysis showed a positive trend in survival associated with ARBs and ACEIs in CRC patients, with up to a 20% increase in disease-free survival, progression-free survival and overall survival [ 20 ]. β-blockers are antagonists of adrenergic receptors, which bind epinephrine and norepinephrine as part of the sympathetic nervous system [ 21 ]. β-blockers restrict prolonged adrenergic stimulation and subsequent renin production [ 11 ].

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