Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.

One of the variants, rs34620296, also showed a trend toward significance in the 23andMe GWAS data ( p = 1 × 10 −3 ; MAF in cases, 0.0025 and MAF in controls, 0.0010), and was previously shown to reduce chaperone activity 36 and affect decidualization 25 .

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It is well established that infection and inflammation represent a highly significant risk factor in preterm birth 5 .

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