Comprehensive metabolomics profiling reveals common metabolic alterations underlying the four major non-communicable diseases in treated HIV infection.

Among changing metabolites, the major metabolites that relative abundance showed a decreasing trend from HIV– NCs to HIV+ NCs and then to HIV+ NCDs were mostly plasmalogen phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), arachidonic acid (AA), D-glutamine, L-glutamine and L-asparagine.

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The major metabolites that relative abundance showed an increasing trend from HIV– NCs to HIV+ NCs and then to HIV+ NCDs were platelet-activating factor (PAF), glycerophosphoethanolamine (GPE), LysoPC, LysoPE, ester PCs, and lipid mediators derived from arachidonic acid, linoleic acid (LA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as L-glutamic acid and N-acetyl-L-aspartic acid.

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