extremely significantp < 0.01
Similar to that seen in the ERG11 gene, the relative ABC2 gene expression was extremely significantly upregulated in four itraconazole-resistant isolates ( p < 0.01) and significant in one itraconazole-resistant isolate ( p < 0.05), as compared with the reference strain ATCC 6258, whereas only two itraconazole-susceptible dose-dependent isolates showed an extremely significant upregulation of ABC2 gene expression compared to the reference strain ATCC 6258 ( p < 0.01, Figure 3A ).