Interestingly, while the accumulation of lipid droplets was observed in the cytoplasm of cells with and without bacteria, the lipid droplet formation was highly significant in cells with internalized bacteria, suggesting the involvement of critical virulence factors of B. pseudomallei .
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<i>Burkholderia pseudomallei</i> interferes with host lipid metabolism via <i>NR1D2</i>-mediated <i>PNPLA2/ATGL</i> suppression to block autophagy-dependent inhibition of infection.
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