Harnessing the Nucleolar DNA Damage Response in Cancer Therapy.

Genes (Basel) · 2021 · PMC8393943 · PMID 34440328

Europe PMC DOI

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highly significantno p-value reported

One of the highly significant CX-5461 synthetic lethal hits was DNA topoisomerase 1 (TOP1), an enzyme that relieves the strain generated by the DNA double helix’s twisting during DNA replication and transcription.

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