Association of <i>TP53</i> Alteration with Tissue Specificity and Patient Outcome of <i>IDH1</i>-Mutant Glioma.

Co-Occurrence of IDH1 Hotspot Mutation and TP53 Alteration Predominantly in Glioma Despite the low frequency of IDH1 mutation in human cancer, further analysis revealed significant to extremely significant co-occurrence of IDH1 and TP53 alterations but mutual exclusivity between IDH2 and TP53 alterations in all three datasets ( Table 2 and Table S2).

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