YY1 Silencing Induces 5-Fluorouracil-Resistance and <i>BCL2L15</i> Downregulation in Colorectal Cancer Cells: Diagnostic and Prognostic Relevance.

Among the mutations analyzed, KRAS was the only one associated with a diagnostic predictive power for BCL2L15 , as the chi-squared test was highly significant ( p = 0.0043), with 79% of BCL2L15 -high expressing subjects in the MUT subgroup ( Figure 6 J).

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As reported in Figure 5 B,E, the contingency analysis through Fisher’s exact test evidenced an extremely significant difference in both YY1 and BCL2L15 expression, with a 78% of YY1 -low expressing samples and a 70% BCL2L15 -low expressing samples within the metastasis subgroup.

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