Besides a nonsignificant trend for an increase in REST in transgenic mice, we evaluated the potential effect of a mutated TARDBP overexpression in well-established REST targets by RT-qPCR.
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Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment.
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The cytoplasmic staining of p-Jun and REST showed the same tendencies, i.e., after an initial decrease, there was a tendency for increasing their values (highly significant in the case of REST), as indicated in Figure 1 A.
The results showed that one downstream REST, CYCS mRNA, was increased almost significantly in the TARDBP transgenic mice ( Figure 3 B).