borderline significantp = 0.06
Similar analysis on mutation-independent risk factors for OS were conducted individuating for the Mayo cohort, age >60 years (5.4, 3.3–9.1) and male gender (1.7, 1.1–2.6), and for the Florence cohort, age >60 years (12.4, 6.3–24.4), male gender (1.6, 1.0–2.7) and leukocyte count ≥11 × 10 9 /L; karyotype in the Mayo ET cohort was borderline significant ( p = 0.06) [ 51 ].