Barely Significant
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Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme.

Pharmaceutics · 2021 · PMC8399849 · PMID 34452102

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an increasing trendno p-value reported
The aortic mRNA expression of osteo-/chondrogenic marker genes Sox9 and Runx-2 showed an increasing trend in all CKD groups with exception of PPi-treated CKD rats and became significant for SBI-425-treated CKD rats.

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