marginal significancep = .052
No significant effects were found at 12-months follow-up (T2 vs T0), though the marginal significance of the regression coefficients of social functioning (β = 0.41, p = .052) and psychosocial functioning (β = 0.42, p = .081; Fig. 5 ) indicated a long-term effect of the intervention at T2. 4 Discussion and conclusion 4.1 Discussion The results of this RCT indicate a positive effect of Op Koers Online for adolescents, an online psychosocial group intervention for adolescents with different types of CI: the intervention had a positive effect on disease-related coping skills (use of relaxation, social competence and information seeking) and on HRQoL (social, school, psychosocial and total).