Vitamin K supplementation and arterial calcification in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial.

For plasma concentrations of PIVKA-II, vitamin K supplementation caused a marginally significant 45% lowering after 1 and 2 years compared with placebo (Table 2) . cfPWV Individual cfPWV measurements are presented in Supplementary data, Figure S5 .

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The cfPWV changes during intervention did not differ significantly between groups, but there was a slight trend towards a higher cfPWV with vitamin K supplementation at the 2-year follow-up. cfPWV results remained unaltered after adjustment for mean arterial pressure obtained just prior to PWV measurements {mean difference in cfPWV at Year 2 after adjustment: 1.1 m/s [95% confidence interval (CI) −0.1 to 2.2, P = 0.07]} (Table 3) .

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