The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation.

By modulating ATP levels through the addition of arsenate, we show that there is indeed a highly significant correlation ( P < 0.0001) between cellular ATP levels and the development of both IbpA and Ph aggregates at the population level ( Fig. 5D and E ), as was also reported previously ( 14 ).

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