Those CYP genes belonged to the lipid hydroxylation pathway, and the specific activation z scores demonstrated an increasing trend of lipid hydroxylation pathway in WE compared with WC (at all ZT time points) and a reduction in SE compared with WE (a z score of more than ± 2 is considered significant) ( Supplemental Figure 1 ; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.140687DS1 ).
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The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease.
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