Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation.

In turn, a highly significant enrichment in genes linked to innate immune activation ( Tnfaip3 , Itgam , C5ar1 , Tlr2 , and Tnf ), cytokine ( Il1b , Il6 , Il10 , Il18 , and Tnf ), chemokine production ( Ccl2 , Ccl3 , Ccl4 , Cxcl1 , Cxcl2 , and Cxcl5 ), and TLR ( Tlr2 and Cd14 ), NF-κB ( Tnip, Tnfaip3 , and Irak3 ), and inflammasome signaling ( Nlrp3 , Il1b , and Il18 ) could be observed within the gene set upregulated in iron-treated FTH-deficient animals ( Figure 3, B and D ).

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