Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model.

JCI Insight · 2021 · PMC8410092 · PMID 34369389

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a notable trendno p-value reported

Although ASO-treated AS mice showed a notable trend toward reduced microcephaly, this improvement did not reach significance ( Figure 3H ).

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