borderline significanceP = 0.02
Effect of trichlormethiazide on HRQOL The subscale of the effects of kidney disease, which represent the impact of kidney disease on patients’ daily lives, was significantly higher, whereas that of sleep was higher with borderline significance during antihypertensive treatment with trichlormethiazide than that without trichlormethiazide ( P = 0.02 and 0.07, respectively) among the subscales of Kidney Disease Quality of Life (KDQOL), kidney disease-specific measure of HRQOL (see Table 3 ).