Discovery of Novel Genetic Risk Loci for Acute Central Serous Chorioretinopathy and Genetic Pleiotropic Effect With Age-Related Macular Degeneration.

Front Cell Dev Biol · 2021 · PMC8417822 · PMID 34490249

Europe PMC DOI

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highly significantp = 2.10 × 10 –7actually significant

Polygenetic risk score (PRS) constructed by using three independent SNPs (rs1410996, rs4698775, and rs2043085) showed highly significant association with CSC ( p = 2.10 × 10 –7 ), with the top 10% of subjects with high PRS showing 6.39 times higher risk than the bottom 10% of subjects with lowest PRS.

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