highly significantp < 10 −15
The resulting clusters were a highly significant predictor of MIC ( p < 10 −15 ; Table 1 (A)) showing that genomically similar isolates tend to have similar MIC values.
The resulting clusters were a highly significant predictor of MIC ( p < 10 −15 ; Table 1 (A)) showing that genomically similar isolates tend to have similar MIC values.
In addition, there were weaker effects of year of collection (with a slight trend for increasing MIC over time); for serotype (with non-disease-associated serotypes tending to have higher MIC); and for host disease status (with non-clinical isolates having higher MIC) (Table 1 (B)).