The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.

PLoS Biol · 2021 · PMC8423302 · PMID 34491982

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highly significantno p-value reported

Moreover, the CpG content of IRGs was also significantly higher than that of ISGs in 8 of the 9 additional species and was highly significant in multiple species, such as dogs and sheep ( Fig 2B ).

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