highly significantP < 0.001
As can be observed in Table 3 , a highly significant ( P < 0.001) depletion of cortical GSH was observed in vehicle-treated pentylenetetrazole mice and pretreatment with 80 and 160 mg/kg AFAD significantly attenuated pentylenetetrazole-induced depletion in GSH compared with the vehicle-treated pentylenetetrazole group.