Barely Significant
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Human osteoclast formation and resorptive function on biomineralized collagen.

Bioact Mater · 2022 · PMC8424427 · PMID 34541399

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a decreasing trendno p-value reported
6 A) suggested that osteoclasts were actively resorbing up to day 21, although a decreasing trend in Ca 2+ content of the medium between 14 and 21 days of culture was observed, which is suggestive of levelling off of resorptive activity and in line with a decrease in TRAP activity observed here.

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an increasing trendno p-value reported
7 I), an increasing trend in CTS-K activity was observed between 7 and 21 days.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.