Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.

23 This finding suggests that clonal evolution of these tumors may be significant, and elegant genomic work has highlighted how these processes might drive relapsed or refractory disease. 10 Although the trend toward a worse outcome in patients with multiple mutations in the COG cohort is intriguing, this observation was not replicated in the UK cohort and may be confounded by the different therapeutic regimens that the patients received.

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