Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain.

In our data and using the same methodological approach to assess volumes, the hippocampal volume of poor CYP2C19 metabolizers was 2.5% larger than in the rest of the sample after adjusting for total subcortical volume, age, sex, and scanning site, but this effect failed to reach significance ( t 601 = 1.04, p = 0.15, one-tailed, Fig. 1 ).

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First, while of only borderline significance, our data essentially replicated the finding reported by Jukic et al.

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