According to previous clinical practice guideline based on systematic reviews, 104 , 125 , 126 AChEIs treatment for dementia contributed to marginally significant improvement of cognitive function, functional and global status, and psycho-behavioural symptoms. 117 , 125 , 127 In mild to moderate AD patients, meta-analyses on AChEIs have revealed the results with cognitive improvements on 1.5 points in MMSE and 2.5 points in ADAS-cog, comparing to the placebo
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Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review.
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