The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism.

Int J Mol Sci · 2021 · PMC8431319 · PMID 34502454

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an increasing trendno p-value reported

The metabolites with the highest VIP scores were lactic acid and glutamate, both showing an increasing trend in their concentrations from the control and mild groups till the severe condition.

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a positive trendno p-value reported

We found that the increase of serum lactic acid strongly correlates in a positive trend with the significant increase of succinic acid, but also xanthine, ornithine, and glutamate in all mild, moderate, and severe COVID-19 patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.