Barely Significant
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A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer's Disease.

Molecules · 2021 · PMC8433978 · PMID 34500775

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a decreasing trendno p-value reported
In the brain’s cerebral cortex, the TXN protein expression level showed a decreasing trend but was not statistically significant in APP/PS1 mice compared with WT mice.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.