R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.

Moreover, rnh1Δ rnh201Δ cells showed highly significant age-dependent accumulations of junctions at tRNAs, which are common sites of R-loop development, and at core Scw1 target genes ( Fig 6F ).

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We found a subtle increase in junctions in older brain cells ( Fig 2A ), although differences were marginally significant at best, reflecting that the coverage and sample number in this data set were low ( Materials and Methods ).

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