Paraquat-induced cholesterol biosynthesis proteins dysregulation in human brain microvascular endothelial cells.

Pathways enrichment of HBMECs exposed to PQ at 10 μM show highly significant enrichment p -value for the two biological pathways—“SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis” and ”Cholesterol Biosynthesis ” ( p value of 1.61 × 10 −08 and 1.11 × 10 −07 , respectively) (Fig. 1 f).

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