NRL<sup>-/-</sup> gene edited human embryonic stem cells generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors.

Finally, this same trend in differential expression between samples was also observed with the rod‐specific photopigment gene RHO , whose expression is regulated synergistically by NRL and CRX 5 , 46 ; expression in NRL −/− OVs was reduced relative to controls at week 14, and this difference was highly significant by week 25.

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