A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

PLoS One · 2021 · PMC8439463 · PMID 34520472

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highly significantno p-value reported

This relationship between the CREBRF R457Q variant and BMI was highly significant (β 1.356, p 1.12 x 10 −13 ), as were the associations with obesity risk (OR 1.305, p 1.12 x 10 −5 ) and diabetes risk (OR 0.586, p 6.68 x 10 −9 after adjusting for BMI) [ 6 ].

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