We observed a highly significant ~8-fold difference in ED 50 s between nonhospitalized patients and hospitalized patients, which is in line with previous reports of WT SARS-CoV-2 binding titers correlating with severity of the disease ( P < 0.0001) ( 26 , 27 ).
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Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination.
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