Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring.

Hum Mol Genet · 2021 · PMC8444454 · PMID 34100083

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The most highly significant expression changes involved genes associated with neurodevelopment (M: Ttr , Coro6 , Pcmtd2 , Gm26953 , Gm27882 ; F: Fezf1, Chrm5 ), neuroprotection (M: Malat1 , Vastm21 ; F: Hcrtr1 ), modulation of the limbic system (M: Vip , Neto2 , Kctd12 , F: Ucn3, Cartpt, Trhr ) and regulation of metabolism (M: Pnrc2 ; F: Map3k15 ) ( Supplementary Material, Table S2A ).

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