Stepwise-Hierarchical Pooled Analysis for Synergistic Interpretation of Meta-analyses Involving Randomized and Observational Studies: Methodology Development.

The effect size in the pooled analysis of balanced studies (ie, studies in which major clinical indicators are similarly distributed between arms) was 1.417 (95% CI 1.171-1.715), and the P value was highly significant at P <.001.

also in 132,142 other papers

This is because the result for the primary endpoint (disease-free survival) of the only phase 3 randomized study on the subject was marginally nonsignificant [ 24 ].

also in 448 other papers