The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles.

Proc Natl Acad Sci U S A · 2021 · PMC8449316 · PMID 34493686

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In the CR protocol, there were highly significant endogenous circadian rhythms in indices of pulmonary function in participants with asthma, with lowest function during the biological night (i.e., the half of the circadian cycle centered around the circadian CBT minimum, corresponding to ∼11:00 PM to 11:00 AM, or the circadian phase span of 270° to 90°; Fig. 3 A and B ).

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