Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS-a randomized, placebo-controlled, double-blind trial.

The main efficacy outcome was a positive trend in pulmonary edema (EVLWI) reduction in the whole study population, which is significant and more pronounced in patients with an initial Sequential Organ Failure Assessment (SOFA) score above 10 inhaling solnatide versus placebo ( P = 0.04; exploratory subgroup analysis).

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