Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial.

However, a comparison between meta-analysis of randomized studies, case-control studies, and observational registry studies with daily administration of ASA all showed a similar and highly significant reduction in the risk of CRC (odds ratio 0.54–0.69) for all, indicating a distinct and robust effect of ASA in primary prevention of CRC [ 13 , 14 ].

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