Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

102 For the T790M mutant EGFR without L858R, although a decreasing trend occurred with the increasing ATP concentration, EAI045 still displayed a promising inhibition effect on the T790M mutation. 102 However, the aforementioned molecular dynamics simulations could not explain this robust EAI045 inhibition of T790M/C797S EGFR mutation. 170 The crystal structure of EAI04

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