Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients.

The SEA output includes an output ranking the proposed target/query interaction by probability (significant, p ≤ 10 –15 ; highly significant, p ≤ 10 –40 ) and by similarity score to an annotated compound/drug (Tanimoto coefficient, max Tc ≥ 0.40, max Tc 1.0 = exact match). 14 The SEA output ( Fig. 5 ) for our hit compounds was potentially informative in identifying additional potential targets for our most potent hit, niclosamide (KCNMA1 and TMPRSS4), as well as GSK-650394 (CAMKK2, AXL, RIPK1).

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