PRDM16, LRP1 and TRPM8 genetic polymorphisms are risk factor for Pakistani migraine patients.

In the present study, PRDM16 rs2651899 showed highly significant differences at the allelic and genotypic level when compared across gender and the particular migraine type with the overall control group which is consistent with the findings of Kaur et al. reporting significant association of this SNP with migraine in the Indian population except for minor allele as they reported T allele as a risk factor compared to G allele in our study ( Kaur et al., 2019 ).

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