Segmented Linear Mixed Model Analysis Reveals Association of the APOEɛ4 Allele with Faster Rate of Alzheimer's Disease Dementia Progression.

Highly significant interactions between main effects of time and ɛ 4 allele were noted for all cognitive measures: MMSE ( ɛ 3/ ɛ 3 versus ɛ 3/ ɛ 4 p = 0.000; ɛ 3/ ɛ 3 versus ɛ 4/ ɛ 4 p = 0.000), CDR-SB ( ɛ 3/ ɛ 3 versus ɛ 4/ ɛ 4 p = 0.000; ɛ 3/ ɛ 4 versus ɛ 4/ ɛ 4 p = 0.000), ADAS-11 ( ɛ 3/ ɛ 3 versus ɛ 4/ ɛ 4 p = 0.000; ɛ 3/ ɛ 4 versus ɛ 4/ ɛ 4 p = 0.000), and MoCA ( ɛ 3/ ɛ 3 versus ɛ 4/ ɛ 4 p = 0.000; ɛ 3/ ɛ 4 versus ɛ 4/ ɛ 4 p = 0.000).

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