Idebenone-Activating Autophagic Degradation of <i>α</i>-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach.

Evid Based Complement Alternat Med · 2021 · PMC8463184 · PMID 34567221

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highly significantno p-value reported

We then explored the dose-dependent effect of Idebenone on α -synuclein levels at concentrations below 3 μ M (0.5 μ M, 1.0 μ M, 1.5 μ M, and 2.0 μ M) and found that the inhibitory effect on the expression of α -synuclein was stable and highly significant at an Idebenone concentration of 2.0 μ M.

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