Estimating the Long-Term Epidemiological Trends and Seasonality of Hemorrhagic Fever with Renal Syndrome in China.

According to the resultant results of joinpoint regression ( Figure 1 ), overall a notable reduction in HFRS morbidity was seen, with AAPC=−6.767 (95% CIs: −10.592 to −2.778; t=−3.278, p =0.001), and yet different stages had different variation trends: a decreasing trend during 1995–2004, with APC=−8.964 (95% CIs: −11.667 to −6.179; t=−6.547, p <0.001); during 2004–2008, with APC=−37.153 (95% CIs: −37.153 to 3.279; t=−1.828, p =0.084); during 2008–2020, with APC=−0.349 (95% CIs: −3.992 to 3.431; t=−0.197, p =0.846), and it seemed to show a cyclical fluctuation with 3–5 years since 2008.

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