It may be significant that miR-378 and miR-30 interact with peroxisome proliferator-activated receptor gamma coactivator 1-alpha ( PPARGC1A ) and peroxisome proliferator-activated receptor gamma coactivator 1-beta ( PPARGC1B ). miR-378a is located in intron 1 of the PPARGC1B gene, which may indicate that there is a regulatory network including PPARGC1B , PGC-1 and miRNA that alter the expression of exercise-induced genes.
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Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity.
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