borderline significantp = 0.052
Respiratory infections in the treatment (non-placebo) cohorts of the STRIVE ENVISION groups rose significantly from 21% of the treatment group at the start of PERSIST to 29% after 144 weeks of treatment ( p = 0.039—by paired χ 2 test of proportions in a single sample) while pulmonary exacerbations rose at the same timepoints from 38% to 46% (borderline significant: p = 0.052).