Tissue of Origin, but Not XCI State, Influences Germ Cell Differentiation from Human Pluripotent Stem Cells.

However, we observed that the hiPSC lines generated from urine-derived cells showed an increasing trend to generate hPGCLCs compared to skin fibroblast-derived lines. hiPSCs are known to retain levels of epigenetic memory from the cell source of origin, which subsequently can result in bias towards differentiation into particular cell lineages [ 55 , 56 , 57 , 58 , 59 ].

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