Early Improvements in Disease Activity Indices Predict Long-Term Clinical Remission Suggested by the Treat-to-Target Strategy in Patients with Ankylosing Spondylitis Receiving TNF-α Inhibitor Treatment.

In the case of normalized ESR or CRP at 3 months, patients with normalized ESR or CRP at 3 months showed only a marginal significance in ASDAS-ID achievement (ESR, OR = 2.04; CI, 0.92–4.55; p = 0.080 and CRP, OR = 2.03; CI, 0.97–4.27; p = 0.060) ( Figure 3 A,C) but showed a significant difference in BASDAI-CRP attainment (ESR, OR = 3.29; CI, 1.42–7.46; p = 0.004 and CRP, OR = 2.73; CI, 1.32–5.62; p = 0.007), especially at 3 and 9 months (ESR: 3 months, p = 0.005; 9 months, p = 0.015 and CRP: 3 months, p < 0.001; 9 months, p = 0.021) ( Figure 3 B,D). 4.

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